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The INTERNET Database of Periodic Tables

There are thousands of periodic tables in web space, but this is the only comprehensive database of periodic tables & periodic system formulations. If you know of an interesting periodic table that is missing, please contact the database curator: Mark R. Leach Ph.D.

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2002

Protein Structure Periodic Tables

From a paper by W. R. Taylor, A 'Periodic Table' for Protein Structures, Nature, 2002 Apr 11;416(6881):657-60

Abstract:

Current structural genomics programs aim systematically to determine the structures of all proteins coded in both human and other genomes, providing a complete picture of the number and variety of protein structures that exist. In the past, estimates have been made on the basis of the incomplete sample of structures currently known. These estimates have varied greatly (between 1,000 and 10,000; see for example refs 1 and 2), partly because of limited sample size but also owing to the difficulties of distinguishing one structure from another. This distinction is usually topological, based on the fold of the protein; however, in strict topological terms (neglecting to consider intra-chain cross-links), protein chains are open strings and hence are all identical. To avoid this trivial result, topologies are determined by considering secondary links in the form of intra-chain hydrogen bonds (secondary structure) and tertiary links formed by the packing of secondary structures. However, small additions to or loss of structure can make large changes to these perceived topologies and such subjective solutions are neither robust nor amenable to automation. Here I formalize both secondary and tertiary links to allow the rigorous and automatic definition of protein topology.

This work has been developed by Efrosini Moutevelis and Derek N. Woolfson in their paper A Periodic Table of Coiled-Coil Protein Structures, J. Mol. Biol. (2009) 385, 726–732.

Abstract:

Coiled coils are protein structure domains with two or more ?-helices packed together via interlacing of side chains known as knob-into-hole packing. We analysed and classified a large set of coiled-coil structures using a combination of automated and manual methods. This led to a systematic classification that we termed a "periodic table of coiled coils", which we have made available here. In this table, coiled-coil assemblies are arranged in columns with increasing numbers of α-helices and in rows of increased complexity. The table provides a framework for understanding possibilities in and limits on coiled-coil structures and a basis for future prediction, engineering and design studies.

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